Thesis on ubiquitin

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Thesis on ubiquitin

Targeting the Ubiquitin Proteasome System - Discovery On Target

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Thesis on ubiquitin

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Search articles by author.THE E4B UBIQUITIN LIGASE By Kyle Andrew Nordquist Dissertation Submitted to the Faculty of the Graduate School of Vanderbilt University in partial fulfillment of the requirements I also thank the members of my thesis committee for .

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To this end, this thesis focuses on understanding the function of E3 ubiquitin ligases and how mutations in these key players in the UPS can drive disease pathology in the heart and brain.

The role of water in the functioning of proteins has been a hot topic over the years. We use terahertz (THz) spectroscopy as an experimental tool to probe the protein-induced fast solvation dynamics of ubiquitin.

In order to investigate the effect of protein flexibility on the changes in the solvation dynami Water - From Interfaces to the Bulk. Summary: The protein encoded by this gene is a member of the deubiquitinating enzyme family. Members of this family are proteases that catalyze the removal of ubiquitin from polypeptides and are divided into five classes, depending on the mechanism of catalysis.

ubiquitin ligase, Mdm2, which also participates in a similar negative feedback loop with p At least seven E3 ubiquitin ligases are known to target p53 for degradation and the This thesis arose from many years of work previously completed in the Benchimol lab.

Former Members - The Henry L. Paulson Laboratory

During my time working on the project, I was fortunate to receive. Here is a list of students who have recently defended their Ph.D. Thesis in Pharmacology, along with a brief description of their thesis work.

8/13/10 Mayra Garcia - Regulation of Hepatitis B Virus Replication by the Ubiquitin-Proteasome Pathway.

Dynamic regulation of histone lysine methylation via the ubiquitin-proteasome system.